DNN 4.5 was released today after a small delay last month.
"A highly focused three month release cycle results in DotNetNuke® 4.5, a new release with integrated Microsoft ASP.NET AJAX support, a web-based installer, and a variety of other high value enhancements designed to improve the user experience." - DotNetNuke Enriches User Experience
I decided to try out a new install, before we perform any upgrades. So, after creating a new database, creating a new directory on the webserver for the site and changing permissions, setting up new site in IIS, and changing the web.config for the connection string, I tried loading the site. I had heard about the new installation wizard and was presented with the following:

I decided to do a custom installation so I could see all of the options.

One of the most common issues people have trying to install DotNetNuke is setting the file/folder permissions. It is nice to see the wizard test these.

Another big issue people have installing DotNetNuke is making sure the connection string is valid. The wizard also supports a database connection test.

Easy install so far....

Nice! You can now configure the host account instead of relying on the defaults.

You can also filter which modules get installed during installation.

And set admin user account and portal porperties instead of using the defaults.

You can also have optional skins and containers to be installed, if available.

And language packs if needed.

And done!
I am very impressed with the new installation wizard. It is good to see checks being performed that will undoubtedly decrease support issues for people who have not setup everything correctly.
After logging into the new site, the first thing I noticed was the different icons.I like the new and clean look of these icons. I also LOVE the new "Show Control Panel" dropdown option.
Something new too is the "Solution Explorer":

This is a convenient interface to the DNN Marketplace. The "DotNetNuke" and "About" tabs still appear to be in beta mode however. It should be interesting to see how this piece develops.
It is very exciting to see this new release, and I will post later how the upgrades go.